Introduction: Fluorine Chemistry

Fluorine in medicinal chemistry.

Fluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicinal chemistry. Quite often, fluorine is introduced to improve the metabolic stability by blocking metabolically labile sites. However, fluorine can ...

Organo-fluorine chemistry III

It is a pleasure to introduce the 3rd in the series of Thematic Issues on organo-fluorine chemistry for the Beilstein Journal of Organic Chemistry (BJOC). These series have become progressively more successful over time in terms of the number and quality of the contributions received. It is also pleasing to note that the profile and impact factor of the journal has increased steadily over this ...

Organo-fluorine chemistry II

It is a pleasure to be able to introduce this second Thematic Series on ‘organo-fluorine chemistry’ within the Beilstein Journal of Organic Chemistry. The series now embeds the subject firmly as a special interest area of the journal. The first series in 2008 presented contributions representing a wide range of organic fluorine chemistry [1-10] and this series continues that trend exploring the...

Fluorine in medicinal chemistry.

Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and pharmacokinetics. This review will highlight the special n...

Fluorine-containing Elastomers Introduction